Jonathan Gilthorpe

Research qualifications: Docent

Contact

jonathan.gilthorpe@umu.se

+46 90 786 94 58

Works at

Associate professor at Department of Medical and Translational Biology Section: Group Jonathan Gilthorpe

Visiting address, view map

Publications Publications

ApoE isoforms inhibit amyloid aggregation of proinflammatory protein S100a9

International Journal of Molecular Sciences, MDPI 2024, Vol. 25, (4)

Ghosh, Shamasree; Tamilselvi, Shanmugam; Williams, Chloe; et al.

A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation

Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences 2024, Vol. 121, (17)

Knyazeva, Anastasia; Li, Shuang; Corkery, Dale P.; et al.

The scaffolding function of LSD1 controls DNA methylation in mouse ESCs

Nature Communications, Springer Nature 2024, Vol. 15, (1)

Malla, Sandhya; Kumari, Kanchan; García-Prieto, Carlos A.; et al.

Reports of batch-dependent suspected adverse events of the BNT162b2 mRNA COVID-19 vaccine: comparison of results from Denmark and Sweden

Medicina, MDPI 2024, Vol. 60, (8)

Manniche, Vibeke; Schmeling, Max; Gilthorpe, Jonathan D.; et al.

Cerebellum, Springer Nature 2024, Vol. 23 : 205-209

Marsili, Luca; Davis, Jennie L.; Espay, Alberto J.; et al.

Genomic evidence for the suitability of Göttingen minipigs with a rare seizure phenotype as a model for human epilepsy

Neurogenetics, Springer Nature 2024, Vol. 25, (2) : 103-117

Najafi, Pardis; Reimer, Christian; Gilthorpe, Jonathan D.; et al.

Mechanical loading modulates AMPK and mTOR signaling in muscle cells

Journal of Proteome Research, American Chemical Society (ACS) 2024, Vol. 23, (10) : 4286-4295

Zhou, Xin; Zhu, Shaochun; Li, Junhong; et al.

Resistance to chicken amyloid arthropathy is associated with a dysfunctional mutation in serum amyloid A

The FASEB Journal, John Wiley & Sons 2023, Vol. 37, (1)

Falker-Gieske, Clemens; Paul, Nora-Fabienne; Spourita, Maria; et al.

Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming

Journal of Translational Medicine, BioMed Central (BMC) 2023, Vol. 21, (1)

Pateras, Ioannis S.; Williams, Chloe; Gianniou, Despoina D.; et al.

Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans

Nature Communications, Springer Nature 2023, Vol. 14

Pu, Longjun; Wang, Jing; Lu, Qiongxuan; et al.

Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis

Cell Reports, Elsevier 2023, Vol. 42, (10)

Tsioras, Konstantinos; Smith, Kevin C.; Edassery, Seby L.; et al.

Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

Cells, MDPI 2022, Vol. 11, (7)

Günther, René; Pal, Arun; Williams, Chloe; et al.

ATP-independent molecular chaperone activity generated under reducing conditions

Protein Science, John Wiley & Sons 2022, Vol. 31, (8)

Leppert, Axel; Chen, Gefei; Lianoudaki, Danai; et al.

Serious side effects exceed the risk of hospitalization with COVID-19 in the Swedish population

Román, Sven; Stahel, Anette; Gilthorpe, Jonathan D.; et al.

Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models

iScience, Elsevier 2021, Vol. 24, (12)

Devoy, Anny; Price, Georgia; De Giorgio, Francesca; et al.

Altered perivascular fibroblast activity precedes ALS disease onset

Nature Medicine, Nature Publishing Group 2021, Vol. 27, (4) : 640-646

Månberg, Anna; Skene, Nathan; Sanders, Folkert; et al.

DNA Editing for Amyotrophic Lateral Sclerosis: Leading Off First Base

The CRISPR Journal, Mary Ann Liebert 2020, Vol. 3, (2) : 75-77

Cunningham, Thomas J.; Fisher, Elizabeth; Fratta, Pietro; et al.

Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice

Acta neuropathologica communications, BMC 2020, Vol. 8, (1)

Lehmann, Manuela; Marklund, Matthew; Bolender, Anna-Lena; et al.

CAM-Delam: an in vivo approach to visualize and quantify the delamination and invasion capacity of human cancer cells

Scientific Reports, Nature Publishing Group 2020, Vol. 10, (1)

Panaliappan, Tamilarasan K.; Slekiene, Lina; Jonasson, Anna-Karin; et al.

Role of pannexin-1 in the cellular uptake, release and hydrolysis of anandamide by T84 colon cancer cells

Scientific Reports, Nature Publishing Group 2019, Vol. 9

Alhouayek, Mireille; Sorti, René; Gilthorpe, Jonathan D.; et al.

The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension

Acta Neuropathologica, New York: Springer 2019, Vol. 138, (1) : 85-101

Keskin, Isil; Forsgren, Elin; Lehmann, Manuela; et al.

GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism

Cancers, MDPI 2019, Vol. 11, (12)

Muthu, Magesh; Kumar, Ranjeet; Khaja, Azharuddin Sajid Syed; et al.

Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer

British Journal of Cancer, Nature Publishing Group 2019, Vol. 120, (2) : 207-217

Singel, Kelly L.; Grzankowski, Kassondra S.; Khan, A. N. M. Nazmul H.; et al.

Intrathecal treatment trial of rituximab in progressive MS: An open-label phase 1b study

Neurology, Wolters Kluwer 2018, Vol. 91, (20) : E1893-E1901

Bergman, Joakim; Burman, Joachim; Gilthorpe, Jonathan D.; et al.

Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin

Journal of Neuroinflammation, BioMed Central 2018, Vol. 15

Lindqvist, Richard; Kurhade, Chaitanya; Gilthorpe, Jonathan D.; et al.

Cytokine levels in interstitial brain fluid in progressive multiple sclerosis measured via intracerebral microdialysis

Multiple Sclerosis Journal, SAGE PUBLICATIONS LTD 2016, Vol. 22 : 511-511

Bergman, J.; Dring, Ann; Wuolikainen, Anna; et al.

Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS

Neurology: Neuroimmunology & Neuroinflammation, Vol. 3, (5)

Bergman, Joakim; Dring, Ann; Zetterberg, Henrik; et al.

Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

PLOS ONE, Vol. 11, (2)

Keskin, Isil; Forsgren, Elin; Lange, Dale J.; et al.

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects

Journal of Neuroinflammation, Vol. 13

Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; et al.

Reactivated herpes simplex infection increases the risk of Alzheimer's disease

Alzheimer's & Dementia: Journal of the Alzheimer's Association, John Wiley & Sons 2015, Vol. 11, (6) : 593-599

Lövheim, Hugo; Gilthorpe, Jonathan; Adolfsson, Rolf; et al.

Herpes simplex infection and the risk of Alzheimer's disease: a nested case-control study

Alzheimer's & Dementia: Journal of the Alzheimer's Association, Vol. 11, (6) : 587-592

Lövheim, Hugo; Gilthorpe, Jonathan; Johansson, Anders; et al.

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 11, (4) : 879-883

Nordin, Joel Z.; Lee, Yi; Vader, Pieter; et al.

Rapid depletion of B lymphocytes by ultra-low-dose rituximab delivered intrathecally

Neurology: Neuroimmunology & Neuroinflammation, Lippincott Williams & Wilkins 2015, Vol. 2, (2)

Svenningsson, Anders; Bergman, Joakim; Dring, Ann; et al.

Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia.

F1000Research, Vol. 2, (148)

Gilthorpe, Jonathan; Oozeer, Fazal; Nash, Julia; et al.

Intense Inflammation and Nerve Damage in Early Multiple Sclerosis Subsides at Older Age: A Reflection by Cerebrospinal Fluid Biomarkers

PLOS ONE, Vol. 8, (5) : e63172-

Khademi, Mohsen; Dring, Ann M.; Gilthorpe, Jonathan D.; et al.

Fatal neuroinflammation in a case of multiple sclerosis with anti-natalizumab antibodies

Neurology, Vol. 80, (10) : 965-967

Svenningsson, Anders; Dring, Ann Marie; Fogdell-Hahn, Anna; et al.

The roof plate boundary is a bi-directional organiser of dorsal neural tube and choroid plexus development.

Development, Vol. 139, (22) : 4261-4270

Broom, Emma R; Gilthorpe, Jonathan; Butts, Thomas; et al.

Multivariate analysis of inflammatory and neuronal injury markers in cerebrospinal fluid of multiple sclerosis: higher levels are associated with younger age

Journal of Neuroimmunology, Vol. 253, (1-2) : 100-100

Khademi, Mohsen; Dring, Ann; Gilthorpe, Jonathan; et al.

MRP14 (S100A9) protein interacts with alzheimer beta-amyloid peptide and induces its fibrillization

PLOS ONE, San Francisco: Public Library of Science 2012, Vol. 7, (3) : e32953-

Zhang, Ce; Liu, Yonggang; Gilthorpe, Jonathan; et al.

Lrrn1 is required for formation of the midbrain-hindbrain boundary and organiser through regulation of affinity differences between midbrain and hindbrain cells in chick

Developmental Biology, Elsevier 2011, Vol. 352, (2) : 341-352

Tossell, Kyoko; Andreae, Laura C; Cudmore, Chloe; et al.

Chick Lrrn2, a novel downstream effector of Hoxb1 and Shh, functions in the selective targeting of rhombomere 4 motor neurons

Neural development, Vol. 4 : 27-

Andreae, Laura C.; Lumsden, Andrew; Gilthorpe, Jonathan D.

Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus

Proceedings of the National Academy of Sciences of the United States of America, The National Academy of Sciences 2009, Vol. 106, (47) : 19895-19900

Scholpp, Steffen; Delogu, Alessio; Gilthorpe, Jonathan D.; et al.

Analysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural development

Neural Development, Vol. 2, (22) : 1-16

Andreae, Laura C; Peukert, Daniela; Lumsden, Andrew; et al.

Characterization of zebrafish PSD-95 gene family members.

Journal of Neurobiology, Vol. 63, (2) : 91-105

Meyer, Martin P; Trimmer, James S; Gilthorpe, Jonathan; et al.

Induction of a parafacial rhythm generator by rhombomere 3 in the chick embryo.

Journal of Neuroscience, Vol. 24, (42) : 9383-9390

Coutinho, Ana P; Borday, Caroline; Gilthorpe, Jonathan; et al.

Multiple levels of transcriptional and post-transcriptional regulation are required to define the domain of Hoxb4 expression

Development, Vol. 130, (12) : 2717-2728

Brend, Tim; Gilthorpe, Jonathan; Summerbell, Dennis; et al.

The migration of cerebellar rhombic lip derivatives.

Development, Vol. 129, (20) : 4719-4728

Gilthorpe, Jonathan; Papantoniou, Elli-Kalliopi; Chédotal, Alain; et al.

Spatially specific expression of Hoxb4 is dependent on the ubiquitous transcription factor NFY.

Development, Vol. 129, (16) : 3887-99

Gilthorpe, Jonathan; Vandromme, Marie; Brend, Tim; et al.

No evidence for ventrally migrating neural tube cells from the mid- and hindbrain.

Developmental Dynamics, Vol. 223, (1) : 163-7

Yaneza, May; Gilthorpe, Jonathan; Lumsden, Andrew; et al.

Neurobiology.

Current Opinion in Neurobiology, Vol. 11, (3) : 259-66

Lumsden, A; Andreae, L; Gilthorpe, Jonathan; et al.

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