Igor Golovlev

Contact

igor.golovlev@umu.se

+46 90 785 18 19

Works at

Staff scientist at Department of Clinical Microbiology Section: Clinical Bacteriology

6C,, Universitetssjukhuset, 22 Umeå universitet, 901 85 Umeå

Analyses of human immune responses to Francisella tularensis identify correlates of protection

Frontiers in Immunology, Frontiers Media S.A. 2023, Vol. 14

Lindgren, Helena; Eneslätt, Kjell; Golovliov, Igor; et al.

Francisella FlmX broadly affects lipopolysaccharide modification and virulence

Cell Reports, Elsevier 2021, Vol. 35, (11)

Chin, Chui-Yoke; Zhao, Jinshi; Llewellyn, Anna C.; et al.

Long-Term Survival of Virulent Tularemia Pathogens outside a Host in Conditions That Mimic Natural Aquatic Environments

Applied and Environmental Microbiology, Elsevier 2021, Vol. 87, (6) : 1-11

Golovliov, Igor; Bäckman, Stina; Granberg, Malin; et al.

Utilization of a tetracycline-inducible system for high-level expression of recombinant proteins in Francisella tularensis LVS

Plasmid, Elsevier 2021, Vol. 115

Sheshko, Valeria; Link, Marek; Golovliov, Igor; et al.

Dissociation between the critical role of ClpB of Francisella tularensis for the heat shock response and the DnaK interaction and its important role for efficient type VI secretion and bacterial virulence

PLoS Pathogens, Public Library of Science 2020, Vol. 16, (4) : 1-27

Alam, Athar; Golovliov, Igor; Javed, Eram; et al.

Vaccine-Mediated Mechanisms Controlling Francisella tularensis SCHU S4 Growth in a Rat Co-Culture System

Pathogens, MDPI 2020, Vol. 9, (5)

Lindgren, Helena; Eneslätt, Kjell; Golovliov, Igor; et al.

Guanylate-Binding Proteins Are Critical for Effective Control of Francisella tularensis Strains in a Mouse Co-Culture System of Adaptive Immunity

Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2020, Vol. 10

Mohammadi, Nasibeh; Lindgren, Helena; Golovliov, Igor; et al.

ClpB mutants of Francisella tularensis subspecies holarctica and tularensis are defective for type VI secretion and intracellular replication

Scientific Reports, Nature Publishing Group 2018, Vol. 8

Alam, Athar; Golovliov, Igor; Javed, Eram; et al.

Vaccine-mediated mechanisms controlling replication of Francisella tularensis in human peripheral blood mononuclear cells using a co-culture system

Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2018, Vol. 8

Eneslätt, Kjell; Golovliov, Igor; Rydén, Patrik; et al.

IFN-gamma extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection

PLoS Pathogens, Public Library Science 2017, Vol. 13, (10)

Wallet, Pierre; Benaoudia, Sacha; Mosnier, Amandine; et al.

An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy

Frontiers in Cellular and Infection Microbiology, Vol. 6

Golovliov, Igor; Lindgren, Helena; Eneslätt, Kjell; et al.

Mechanisms of heme utilization by Francisella tularensis

PLOS ONE, Vol. 10, (3)

Lindgren, Helena; Lindgren, Lena; Golovliov, Igor; et al.

Identification of Mechanisms for Attenuation of the FSC043 Mutant of Francisella tularensis SCHU S4

Infection and Immunity, American Society for Microbiology 2014, Vol. 82, (9) : 3622-3635

Lindgren, Marie; Tancred, Linda; Golovliov, Igor; et al.

A Delta clpB Mutant of Francisella tularensis Subspecies holarctica Strain, FSC200, Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia

PLOS ONE, Public Library of Science 2013, Vol. 8, (11) : e78671-

Golovlev, Igor; Twine, Susan M.; Shen, Hua; et al.

The Francisella tularensis LVS ΔpdpC mutant exhibits a unique phenotype during intracellular infection

BMC Microbiology, BioMed Central 2013, Vol. 13

Lindgren, Marie; Bröms, Jeanette E.; Meyer, Lena; et al.

Administration of a donor of nitric oxide inhibits mglA expression of intracellular Francisella tularensis and counteracts phagosomal escape and subversion of TNF-α secretion

Journal of Medical Microbiology, Vol. 30, (11) : 1570-1583

Tancred, Linda; Telepnev, Maxim; Golovlev, Igor; et al.

Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization

Vaccine, Vol. 28, (7) : 1824-1831

Conlan, J Wayne; Shen, Hua; Golovliov, Igor; et al.

The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis

BMC Microbiology, Vol. 10 : 227-

Forslund, Anna-Lena; Salomonsson, Emelie Näslund; Golovliov, Igor; et al.

Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model

PLOS ONE, Vol. 4, (5) : e5463-

Kadzhaev, Konstantin; Zingmark, Carl; Golovliov, Igor; et al.

The 58-kilodalton major virulence factor of Francisella tularensis is required for efficient utilization of iron

Infection and Immunity, Vol. 77, (10) : 4429-4436

Lindgren, Helena; Honn, Marie; Golovlev, Igor; et al.

Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensis

Infection and Immunity, Vol. 77, (8) : 3424-3431

Salomonsson, Emelie; Kuoppa, Kerstin; Forslund, Anna-Lena; et al.

MglA and Igl proteins contribute to the modulation of Francisella tularensis live vaccine strain-containing phagosomes in murine macrophages

Infection and Immunity, Vol. 76, (8) : 3502-3510

Bönquist, Linda; Lindgren, Helena; Golovliov, Igor; et al.

Adaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitro

Infection and Immunity, Vol. 76, (10) : 4479-4488

Hazlett, Karsten RO; Caldon, Seth D; McArthur, Debbie G; et al.

The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice

Molecular Microbiology, Oxford: Blackwells 2008, Vol. 67, (6) : 1384-1401

Meibom, Karin L; Dubail, Iharilalao; Dupuis, Marion; et al.

Expression of iglC is mecessary for intracellular growth and induction of apoptosis in murine macrophages by Francisella tularensis

Microbial Pathogenesis, London: Academic P. 2004, Vol. 37, (5) : 225-230

Lai, Xin-He; Golovliov, Igor; Sjöstedt, Anders

The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis

Forslund, Anna-Lena; Salomonsson, Emelie; Goloviov, Igor; et al.

Characterization of the spontaneous mutant FSC043 of Francisella tularensis subspecies tularensis

Lindgren, Marie; Tancred, Linda; Golovlev, Igor; et al.

View publications in DiVA

Research groups

Group member

Anders Sjöstedt

Research projects

1 January 2021 until 31 December 2023

The type VI secretion system of Francisella tularensis – elucidation of its structure and assembly/disassembly control

1 January 2021 until 31 December 2025

Development of a new tularemia vaccine