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Gunilla Olivecrona
Research qualifications:
Docent
Contact
E-mail
gunilla.olivecrona@umu.se
Phone
Works at
Affiliation
Affiliated as professor emerita at
Department of Medical Biosciences
Location
By 6M, vån 3, Sjukhusområdet
Umeå universitet, 901 87 Umeå
Publications
Publications
Research
Research
2024
Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice
Cardiovascular Research
Modder, Melanie; Panhuis, Wietse In Het; Li, Mohan; et al.
2023
Visualizing increased uptake of [18F]FDG and [18F]FTHA in kidneys from obese high-fat diet fed C57BL/6J mice using PET/CT ex vivo
PLOS ONE
, Public Library of Science (PLoS) 2023, Vol. 18
Nyrén, Rakel; Scherman, Henrik; Axelsson, Jan; et al.
2023
Role of lipoprotein lipase activity measurement in the diagnosis of familial chylomicronemia syndrome: diagnosis of the Familial Chylomicronemia Syndrome
Journal of Clinical Lipidology
, Elsevier 2023, Vol. 17, (2) : 272-280
Rioja, José; Ariza, María José; Benítez-Toledo, María José; et al.
2022
ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy
Journal of Lipid Research
, American Society for Biochemistry and Molecular Biology 2022, Vol. 63, (7)
Deng, Mingjuan; Kutrolli, Elda; Sadewasser, Anne; et al.
2022
Lipoprotein size is a main determinant for the rate of hydrolysis by exogenous LPL in human plasma
Journal of Lipid Research
, American Society for Biochemistry and Molecular Biology 2022, Vol. 63, (1)
Kovrov, Oleg; Landfors, Fredrik; Saar-Kovrov, Valeria; et al.
2020
Maternal Adipose Tissue Expansion, A Missing Link in the Prediction of Birth Weight Centile
Journal of Clinical Endocrinology and Metabolism
, Oxford University Press 2020, Vol. 105, (3) : E814-E825
Jarvie, Eleanor M.; Stewart, Frances M.; Ramsay, Jane E.; et al.
2020
Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism
Proceedings of the National Academy of Sciences of the United States of America
, National Academy of Sciences 2020, Vol. 117, (8) : 4337-4346
Kristensen, Kristian K.; Leth-Espensen, Katrine Zinck; Mertens, Haydyn D. T.; et al.
2020
Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue
Molecular Metabolism
, Elsevier 2020, Vol. 40
Ruppert, Philip M. M.; Michielsen, Charlotte C. J. R.; Hazebroek, Eric J.; et al.
2019
On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
Journal of Lipid Research
, American Society for Biochemistry and Molecular Biology 2019, Vol. 60, (4) : 783-793
Kovrov, Oleg; Kristensen, Kristian Kølby; Larsson, Erika; et al.
2019
Lipoprotein lipase in mouse kidney: effects of nutritional status and high-fat diet
American Journal of Physiology - Renal Physiology
, American Physiological Society 2019, Vol. 316, (3) : F558-F571
Nyrén, Rakel; Makoveichuk, Elena; Malla, Sandhya; et al.
2019
Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[S]
Journal of Lipid Research
, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2019, Vol. 60, (10) : 1741-1754
Oteng, Antwi-Boasiako; Ruppert, Philip M. M.; Boutens, Lily; et al.
2018
Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet
European Journal of Nutrition
, Springer 2018, Vol. 57, (8) : 2877-2886
Blomquist, Caroline; Chorell, Elin; Ryberg, Mats; et al.
2018
Lipoprotein Lipase Deficiency Impairs Bone Marrow Myelopoiesis and Reduces Circulating Monocyte Levels
Arteriosclerosis, Thrombosis and Vascular Biology
, Vol. 38, (3) : 509-519
Chang, Chuchun L.; Garcia-Arcos, Itsaso; Nyrén, Rakel; et al.
2018
A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
Proceedings of the National Academy of Sciences of the United States of America
, National Academy of Sciences 2018, Vol. 115, (26) : E6020-E6029
Kristensen, Kristian K.; Midtgaard, Søren Roi; Mysling, Simon; et al.
2017
On the regulatory importance of 27-hydroxycholesterol in mouse liver
Journal of Steroid Biochemistry and Molecular Biology
, Elsevier 2017, Vol. 169 : 10-21
Heverin, Maura; Ali, Zeina; Olin, Maria; et al.
2017
High concentrations of Angiopoietin-like Protein 4 detected in serum from patients with rheumatoid arthritis can be explained by non-specific antibody reactivity
PLOS ONE
, Vol. 12, (1)
Makoveichuk, Elena; Ruge, Toralph; Nilsson, Solveig; et al.
2017
TNF-alpha decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
, Elsevier 2017, Vol. 1862, (5) : 533-540
Makoveichuk, Elena; Vorrsjö, Evelina; Olivecrona, Thomas; et al.
2017
Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition
JOURNAL OF LIPID RESEARCH
, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017, Vol. 58, (5) : 840-852
Meyers, Nathan L.; Larsson, Mikael; Vorrsjo, Evelina; et al.
2017
Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry
Journal of Lipid Research
, Vol. 58, (1) : 279-288
Reimund, Mart; Kovrov, Oleg; Olivecrona, Gunilla; et al.
2016
Peroxisome proliferator-activated receptor activation favours selective subcutaneous lipid deposition by coordinately regulating lipoprotein lipase modulators, fatty acid transporters and lipogenic enzymes
Acta Physiologica
, Vol. 217, (3) : 227-239
Blanchard, P. G.; Turcotte, V.; Cote, M.; et al.
2016
Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitis
Journal of Clinical Lipidology
, Vol. 10, (1) : 92-100
Jose Ariza, Maria; Luis Martinez-Hernandez, Pedro; Ibarretxe, Daiana; et al.
2016
Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells
The FEBS Journal
, Wiley-Blackwell 2016, Vol. 283, (13) : 2476-2493
Klinger, Stine C.; Højland, Anne; Jain, Shweta; et al.
2016
Free fatty acid transfer across the placenta facilitated by lipoprotein lipase and its relationship with fetal adiposity
British Journal of Obstetrics and Gynecology
, Vol. 123 : 86-86
McMurray, C.; Jordan, F.; Olivecrona, Gunilla; et al.
2016
The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding
eLIFE
, Vol. 5
Mysling, Simon; Kolby Kristensen, Kristian; Larsson, Mikael; et al.
2016
Diabetes and Hypertension Consistently Predict the Presence and Extent of Coronary Artery Calcification in Symptomatic Patients: A Systematic Review and Meta-Analysis
International Journal of Molecular Sciences
, Basel, Switzerland: MDPI 2016, Vol. 17, (9)
Nicoll, Rachel; Zhao, Ying; Ibrahimi, Pranvera; et al.
2016
Role of lipoprotein lipase in lipid metabolism
Current Opinion in Lipidology
, Vol. 27, (3) : 233-241
Olivecrona, Gunilla
2016
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity
Journal of Clinical Investigation
, American Society for Clinical Investigation 2016, Vol. 126, (7) : 2706-2720
Schmidt, Vanessa; Schulz, Nadja; Yan, Xin; et al.
2016
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile
Nature Communications
, Vol. 7
Valleix, Sophie; Verona, Guglielmo; Jourde-Chiche, Noémie; et al.
2015
TREM2 regulates microglial cell activation in response to demyelination in vivo
Acta Neuropathologica
, Vol. 129, (3) : 429-447
Cantoni, Claudia; Bollman, Bryan; Licastro, Danilo; et al.
2015
Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides
in vivo
European Journal of Medicinal Chemistry
, Elsevier 2015, Vol. 103 : 191-209
Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; et al.
2015
A Pressure-dependent Model for the Regulation of Lipoprotein Lipase by Apolipoprotein C-II
Journal of Biological Chemistry
, Bethesda: American Society for Biochemistry and Molecular Biology 2015, Vol. 290, (29) : 18029-18044
Meyers, Nathan L; Larsson, Mikael; Olivecrona, Gunilla; et al.
2015
A pressure-dependent model for the regulation of lipoprotein lipase by apolipoprotein C-II
The FASEB Journal
, Vol. 29, (Supplement 1)
Meyers, Nathan; Larsson, Mikael; Olivecrona, Gunilla; et al.
2015
Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1)
Journal of Biological Chemistry
, American Society for Biochemistry and Molecular Biology 2015, Vol. 290, (22) : 13919-13934
Reimund, Mart; Larsson, Mikael; Kovrov, Oleg; et al.
2015
The tissue distribution of lipoprotein lipase determines where chylomicrons bind
Journal of Lipid Research
, Vol. 56, (3) : 588-598
Savonen, Roger; Hiden, Michaela; Hultin, Magnus; et al.
2015
Acute alcohol consumption downregulates lipoprotein lipase activity
in vivo
Metabolism: Clinical and Experimental
, Elsevier 2015, Vol. 64, (11) : 1592-1596
Zemankova, Katerina; Makoveichuk, Elena; Vlasakova, Zuzana; et al.
2014
Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise
Proceedings of the National Academy of Sciences of the United States of America
, Vol. 111, (11) : E1043-E1052
Catoire, MilSNe; Alex, Sheril; Paraskevopulos, Nicolas; et al.
2014
Identification of a small molecule that stabilizes lipoprotein lipase
in vitro
and lowers triglycerides
in vivo
Biochemical and Biophysical Research Communications - BBRC
, Elsevier 2014, Vol. 450, (2) : 1063-1069
Larsson, Mikael; Caraballo, Rémi; Ericsson, Madelene; et al.
2014
Response of angiopoietin-like proteins 3 and 4 to haemodialysis
International Journal of Artificial Organs
, Vol. 37, (1) : 13-20
Mahmood, Dana; Makoveichuk, Elena; Nilsson, Solveig; et al.
2014
Lipoprotein lipase activity is favoured by peritoneal dialysis compared to hemodialysis
Scandinavian Journal of Clinical and Laboratory Investigation
, Vol. 74, (4) : 296-300
Mahmood, Dana; Nilsson, Solveig; Olivecrona, Gunilla; et al.
2013
Hvorfor hypertriglyseridemi fø rer til pankreatitt
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
, Den norske legeforening 2013, Vol. 133, (1) : 14-15
Christophersen, Bjørn; Sørby, Randi; Osmundsen, Harald; et al.
2013
Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4
American Journal of Respiratory and Critical Care Medicine
, Vol. 188, (2) : 240-248
Drager, Luciano F.; Yao, Qiaoling; Hernandez, Karen L.; et al.
2013
Depletion of FOXP3(+) regulatory T cells promotes hypercholesterolemia and atherosclerosis
Journal of Clinical Investigation
, Vol. 123, (3) : 1323-1334
Klingenberg, Roland; Gerdes, Norbert; Badeau, Robert M; et al.
2013
Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets
Journal of Biological Chemistry
, Vol. 288, (47) : 33997-34008
Larsson, Mikael; Vorrsjö, Evelina; Talmud, Philippa; et al.
2013
Inactivation of lipoprotein lipase in 3T3-L1 adipocytes by angiopoietin-like protein 4 requires that both proteins have reached the cell surface
Biochemical and Biophysical Research Communications - BBRC
, Elsevier 2013, Vol. 441, (4) : 941-946
Makoveichuk, Elena; Vorrsjö, Evelina; Olivecrona, Thomas; et al.
2013
Fasting apolipoprotein B48 is a marker for peripheral arterial disease in type 2 diabetes
Acta Diabetologica
, Vol. 50, (3) : 383-389
Mancera-Romero, J.; Sanchez-Chaparro, M. A.; Rioja, J.; et al.
2013
Maternal Obesity Is Associated With the Formation of Small Dense LDL and Hypoadiponectinemia in the Third Trimester
Journal of Clinical Endocrinology and Metabolism
, Vol. 98, (2) : 643-652
Meyer, Barbara J.; Stewart, Frances M.; Brown, Elizabeth A.; et al.
2012
Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea
European Heart Journal
, Oxford: Oxford University Press 2012, Vol. 33, (6) : 783-U33
Drager, Luciano F.; Li, Jianguo; Shin, Mi-Kyung; et al.
2012
Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue.
BMC Physiology
, BioMed Central (BMC) 2012, Vol. 12 : 13-
Kroupa, Olessia; Vorrsjö, Evelina; Stienstra, Rinke; et al.
2012
Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury
American Journal of Physiology - Renal Physiology
, Vol. 303, (3) : F437-F448
Li, Shenyang; Nagothu, Kiran; Ranganathan, Gouri; et al.
2012
Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed
Biochemical and Biophysical Research Communications - BBRC
, San Diego: Elsevier 2012, Vol. 425, (2) : 138-143
Makoveichuk, Elena; Sukonina, Valentina; Kroupa, Olessia; et al.
View publications in DiVA
Research groups
Head of research
Gunilla Olivecrona
Research projects
28 February 2007 until 31 December 2009
Role of lipoprotein lipase for plasma lipid transport
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