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Staff photo Gerhard Gröbner

Gerhard Gröbner

Professor of biophysical chemistry and responsible for the national NMR infrastructure. Researches biological membranes with a focus on proteins involved in cell death. Leads Biological Chemistry.

Research qualifications: Docent

Works at

Affiliation
Location
KB.A4, Linnaeus väg 10, (rum: A4.31.01) Umeå universitet, 901 87 Umeå

I work as a biophysical chemist to unravel the role of biological membranes in life - from basic function to involvement in diseases. To provide molecular information about membranes, ranging from their lipid matrix to their proteins, we employ NMR spectroscopy where we have world-class instrumentation in-house (Scilifelab platform; UmU node).

Our current focus is on mitochondrial membrane systems to address the relation between membrane environment and functioning of their proteins. Focus is on the Bcl-2 protein family which is involved in regulation of programmed cell death (apoptosis) and plays a notorious role in many cancers. Our NMR approach is complemented by a range of biochemical/biophysical methods and neutron reflectometry in collaboration with ESS (Lund).  In the long-term we will to shed fundamentally new light onto the molecular mechanism by which cell-protecting Bcl-2 proteins function in a membrane environment and open up new avenues for innovative cancer drugs against those proteins.

Biography

I obtained myPh.D. in the area of physical chemistry under the supervision of Prof. G. Kothe at the University of Stuttgart, DE. After a postdoctorial stay in the group of Prof. A. Watts (Biochemstry, Oxford University, UK), I started working in Umeå in 2000 and become Professor in Biophysical Chemistry here in 2008.

ACS Chemical Biology, American Chemical Society (ACS) 2024, Vol. 19, (2) : 563-574
Altincekic, Nadide; Jores, Nathalie; Löhr, Frank; et al.
Biophysical Journal, Elsevier 2023, Vol. 122, (3S1) : 232a-232a
Clifton, Luke A.; Ul Mushtaq, Ameeq; Ådén, Jörgen; et al.
Science Advances, American Association for the Advancement of Science (AAAS) 2023, Vol. 9, (22)
Clifton, Luke A.; Wacklin-Knecht, Hanna P.; Ådén, Jörgen; et al.
Journal of Translational Medicine, BioMed Central (BMC) 2023, Vol. 21, (1)
Dudka, Ilona; Lundquist, Kristina; Wikström, Pernilla; et al.
eLIFE, eLife Sciences Publications, Ltd 2022, Vol. 11
Nadeem, Aftab; Berg, Alexandra; Pace, Hudson; et al.
Biomolecular NMR Assignments, Springer 2022, Vol. 16 : 75-79
Ul Mushtaq, Ameeq; Ådén, Jörgen; Alam, Athar; et al.
Biophysical Journal, Elsevier 2022, Vol. 121, (23) : 4517-4525
Ul Mushtaq, Ameeq; Ådén, Jörgen; Ali, Katan; et al.
Journal of Pharmaceutical and Biomedical Analysis, Elsevier 2021, Vol. 197
Dudka, Ilona; Chachaj, Angelika; Sebastian, Agata; et al.
Ecology and Evolution, John Wiley & Sons 2021, Vol. 11, (7) : 3159-3183
Fohringer, Christian; Dudka, Ilona; Spitzer, Robert; et al.
Communications Biology, Springer Nature 2021, Vol. 4, (1)
Ul Mushtaq, Ameeq; Ådén, Jörgen; Clifton, Luke A.; et al.
Molecules, MDPI 2021, Vol. 26, (5)
Ul Mushtaq, Ameeq; Ådén, Jörgen; Sparrman, Tobias; et al.
Diagnostics (Basel), MDPI 2020, Vol. 10, (11)
Chachaj, Annika; Matkowski, Rafal; Gröbner, Gerhard; et al.
BMC Cancer, BioMed Central 2020, Vol. 20, (1)
Dudka, Ilona; Thysell, Elin; Lundquist, Kristina; et al.
Solid-state NMR: applications in biomembrane structure, Institute of Physics Publishing (IOPP) 2020 : 1.1-1.30
Gröbner, Gerhard; Williamson, Philip
Protein Expression and Purification, Elsevier 2020, Vol. 172
Ådén, Jörgen; Ul Mushtaq, Ameeq; Dingeldein, Artur P. G.; et al.
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 394A-394A
Ådén, Jörgen; Ul Mushtaq, Ameeq; Sparrman, Tobias; et al.
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 508A-508A
Alam, Md Khorshed; Vinklarek, Ivo; Gröbner, Gerhard; et al.
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 508A-508A
Dingeldein, Artur P. G.; Sparrman, Tobias; Ådén, Jörgen; et al.
Protein Expression and Purification, Elsevier 2019, Vol. 158 : 20-26
Dingeldein, Artur Peter Günther; Lindberg, Mikael J.; Ådén, Jörgen; et al.
European Biophysics Journal, Springer 2019, Vol. 48 : S170-S170
Koukalova, A.; Pokorna, S.; Lidman, Martin; et al.
European Biophysics Journal, Springer 2019, Vol. 48 : S177-S177
Sousa, T.; Pokorna, S.; Castro, R.; et al.
Biochimica et Biophysica Acta - Biomembranes, Elsevier 2018, Vol. 1860, (12) : 2644-2654
Dingeldein, Artur P. G.; Sparrman, Tobias; Gröbner, Gerhard
BIOPHYSICAL JOURNAL
Dingeldein, Artur Peter Günther; Sparrman, Tobias; Åden, Jörgen; et al.
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
Biophysical Journal, Vol. 112, (10) : 2147-2158
Dingeldein, Artur Peter Günther; Pokorna, Sarka; Lidman, Martin; et al.
Scientific Reports, Vol. 7
Koukalova, Alena; Amaro, Mariana; Aydogan, Gokcan; et al.
European Biophysics Journal, Vol. 46 : S128-S128
Velas, L.; Koukalova, A.; Amaro, M.; et al.
Biophysical Journal, Vol. 110, (3) : 59A-60A
Dingeldein, Artur P. G.; Lidman, Martin; Sparrman, Tobias; et al.
Biophysical Journal, Elsevier 2016, Vol. 110, (3) : 473A-473A
Lidman, Martin; Dingeldein, Artur; Pokorná, Šárka; et al.
Biochimica et Biophysica Acta - Biomembranes, Vol. 1858, (6) : 1288-1297
Lidman, Martin; Pokorná, Šárka; Dingeldein, Artur P. G.; et al.
Journal of Photochemistry and Photobiology. B: Biology, Elsevier 2015 : 383-394
Cheregi, Otilia; Miranda, Hélder; Gröbner, Gerhard; et al.
Biophysical Journal, Cell Press 2015, Vol. 108, (2) : 251A-252A
Dingeldein, Artur P G; Lidman, Martin; Pokorna, Sarka; et al.
Advances in Biological Solid-State NMR: proteins and Membrane-Active Peptides, Cambridge, GBR: Royal Society of Chemistry 2014 : 113-132
Lidman, Martin; Wallgren, Marcus; Gröbner, Gerhard
Vestergren, Johan; Ouattara, Korodjouma; Schleucher, Jurgen; et al.
Biophysical Journal, Cell Press 2014, Vol. 107, (8) : 1950-1961
Weise, Christoph F; Login, Frédéric H; Ho, Oanh; et al.
Journal of Agricultural and Food Chemistry, Vol. 61, (29) : 7061-7069
Kaffarnik, Stefanie; Ehlers, Ina; Gröbner, Gerhard; et al.
Kemivärlden biotech / kemisk tidskrift, Journal of Chemistry and Biotechnology 2013, (3) : 35-37
Schleucher, Jürgen; Gröbner, Gerhard; Karlsson, Göran
Biophysical Journal, Vol. 104, (2) : 501A-502A
Vestergren, Johan E.; Vincent, Andrea G.; Persson, Per; et al.
Forest facts, SLU 2013, (4)
Vincent, Andrea G; Ilstedt, Ulrik; Vestergren, Johan; et al.
Plant and Soil, Dordrecht: Springer 2013, Vol. 367, (1-2) : 149-162
Vincent, Andrea G.; Vestergren, Johan; Gröbner, Gerhard; et al.
Faraday discussions, RSC Publishing 2013, Vol. 161 : 499-513
Wallgren, Marcus; Beranova, Lenka; Pham, Quoc Dat; et al.
Biophysical Journal, Vol. 104, (2) : 249A-249A
Wallgren, Martin; Pham, Quoc Dat; Lidman, Martin; et al.
ACS Macro Letters, American Chemical Society (ACS) 2013, Vol. 2, (6) : 511-517
Yu, Junchun; Yao, Mingguang; Gröbner, Gerhard; et al.
Physical Chemistry, Chemical Physics - PCCP, Royal Society of Chemistry 2012, Vol. 14, (42) : 14516-14522
Beranová, Lenka; Humpolíčková, Jana; Sýkora, Jan; et al.
Magnetic Resonance Imaging, Elsevier 2012, Vol. 30, (3) : 413-421
Filippov, Andrey; Munavirov, Bulat; Gröbner, Gerhard; et al.
Journal of Structural Biology, San Diego, CA, USA: Academic Press 2012, Vol. 180, (1) : 174-189
Norlin, Nils; Hellberg, Magnus; Filippov, Andrey; et al.
Angewandte Chemie International Edition, Vol. 51, (19) : 4653-4657
Orwick, Marcella C; Judge, Peter J; Procek, Jan; et al.
Environmental Science and Technology, American Chemical Society (ACS) 2012, Vol. 46, (7) : 3950-3956
Vestergren, Johan; Vincent, Andrea G; Jansson, Mats; et al.
Biogeochemistry, Springer 2012, Vol. 108, (1-3) : 485-499
Vincent, Andrea G; Schleucher, Jürgen; Gröbner, Gerhard; et al.

Research groups

Head of research
Gerhard Gröbner Lab

Research projects

1 January 2007 until 31 December 2009