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Umeå University
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Staff photo Florentin Späth

Florentin Späth

Affiliated as researcher and consultant in hematology conducting translational research with focus on lymphoproliferative disorders.

Contact

E-mail
florentin.spaeth@umu.se
Phone
+46 90 785 16 32

Works at

Affiliation
Affiliated as physician at Department of Diagnostics and Intervention Section: Oncology
Location
27C, Målpunkt QC31, NUS, Norrlands universitetssjukhus Cancercentrum, sektionen för hematologi, 901 85 Umeå

Affiliated as researcher at the Department of Radiation Sciences (Oncology unit) and Consultant in hematology. My research focus is on challenges met in clinical care of patients with hematological malignancies with a particular interest in multiple myeloma, chronic lymphocytic leukemia, and their allied precursor conditions. I have considerable knowledge in performing translational research projects using high quality biobanks with an aim towards improving prognostication and diagnostics.

Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
Blood Cancer Journal, Springer Nature 2024, Vol. 14, (1)
Thomsen, Hauke; Chattopadhyay, Subhayan; Weinhold, Niels; et al.
Deciphering the genetics and mechanisms of predisposition to multiple myeloma
Nature Communications, Springer Nature 2024, Vol. 15, (1)
Went, Molly; Duran-Lozano, Laura; Halldorsson, Gisli H.; et al.
Genetic drivers in the natural history of chronic lymphocytic leukemia development as early as 16 years before diagnosis
Blood, Elsevier 2023, Vol. 142, (16) : 1399-1403
Kolijn, P. Martijn; Späth, Florentin; Khouja, Mouhamad; et al.
Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6
Blood Cancer Journal, Springer Nature 2022, Vol. 12, (4)
Clay-Gilmour, Alyssa; Chattopadhyay, Subhayan; Hildebrandt, Michelle A. T.; et al.
Progression patterns in monoclonal gammopathy of undetermined significance and multiple myeloma outcome: a cohort study in 42 patients
Experimental Hematology & Oncology, BioMed Central (BMC) 2022, Vol. 11, (1)
Tahiru, Widad; Izarra Santamaria, Antonio; Hultdin, Johan; et al.
Pre-diagnostic levels of sVEGFR2, sTNFR2, sIL-2Rα and sIL-6R are associated with glioma risk: A nested case–control study of repeated samples
Cancer Medicine, John Wiley & Sons 2022, Vol. 11, (4) : 1016-1025
Wu, Wendy Yi-Ying; Späth, Florentin; Wibom, Carl; et al.
Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: an exposome-wide analysis
International Journal of Cancer, John Wiley & Sons 2021, Vol. 148, (9) : 2115-2128
Saberi Hosnijeh, Fatemeh; Casabonne, Delphine; Nieters, Alexandra; et al.
Intraindividual long-term immune marker stability in plasma samples collected in median 9.4 Years apart in 304 adult cancer-free individuals
Cancer Epidemiology, Biomarkers and Prevention, Philadephia: American Association for Cancer Research 2021, Vol. 30, (11) : 2052-2058
Späth, Florentin; Wu, Wendy Yi-Ying; Krop, Esmeralda J.M.; et al.
Identification of Pre-Diagnostic Metabolic Patterns for Glioma Using Subset Analysis of Matched Repeated Time Points
Cancers, MDPI 2020, Vol. 12, (11)
Jonsson, Pär; Antti, Henrik; Späth, Florentin; et al.
Healthy lifestyle and the risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition study
International Journal of Cancer, John Wiley & Sons 2020, Vol. 147, (6) : 1649-1656
Naudin, Sabine; Margalef, Marta Solans; Hosnijeh, Fatemeh Saberi; et al.
Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition.
European Journal of Nutrition, Springer Berlin/Heidelberg 2020, Vol. 59, (2) : 813-823
Solans, Marta; Benavente, Yolanda; Saez, Marc; et al.
Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)
Scientific Reports, Nature Publishing Group 2019, Vol. 9
Espín-Pérez, Almudena; Hebels, Dennie G. A. J.; Kiviranta, Hannu; et al.
DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia
Environment International, Vol. 126 : 24-36
Georgiadis, Panagiotis; Gavriil, Marios; Rantakokko, Panu; et al.
Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition
International Journal of Cancer, John Wiley & Sons 2019, Vol. 145, (1) : 122-131
Solans, Marta; Benavente, Yolanda; Saez, Marc; et al.
Molecular epidemiology approach: nested case-control studies in glioma and lymphoid malignancies
Umeå University medical dissertations, 2016
Späth, Florentin
Immune marker changes and risk of multiple myeloma: a nested case-control study using repeated prediagnostic blood samples
Haematologica, Ferrata Storti Foundation 2019, Vol. 104, (12) : 2456-2464
Späth, Florentin; Wibom, Carl; Krop, Esmeralda; et al.
Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma
Leukemia, Nature Publishing Group 2019, Vol. 33, (7) : 1817-1821
Thomsen, Hauke; Chattopadhyay, Subhayan; Weinhold, Niels; et al.
Long-term real-world results of ibrutinib therapy in patients with relapsed or refractory chronic lymphocytic leukemia: 30-month follow up of the Swedish compassionate use cohort
Haematologica, Ferrata Storti Foundation 2019, Vol. 104, (5) : E208-E210
Winqvist, Maria; Andersson, Per-Ola; Asklid, Anna; et al.
Pre-diagnostic plasma metabolites linked to future brain tumor development
Neuro-Oncology, Oxford University Press 2018, Vol. 20 : 288-289
Björkblom, Benny; Jonsson, Pär; Späth, Florentin; et al.
Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis
BMC Genomics, Vol. 18
Georgiadis, Panagiotis; Liampa, Irene; Hebels, Dennie G; et al.
MicroRNA profile for health risk assessment: environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery
Scientific Reports, Vol. 7
Krauskopf, Julian; de Kok, Theo M; Hebels, Dennie G; et al.
Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis
Cancer Research, American Association for Cancer Research 2017, Vol. 77, (6) : 1408-1415
Späth, Florentin; Wibom, Carl; Krop, Esmeralda J. M.; et al.
Soluble B-cell activation marker of sCD27 and sCD30 and future risk of B-cell lymphomas: a nested case-control study and meta-analyses
International Journal of Cancer, John Wiley & Sons 2016, Vol. 138, (10) : 2357-2367
Hosnijeh, Fatemeh Saberi; Portengen, Lutzen; Späth, Florentin; et al.
Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study
Tumor Biology, Vol. 37, (8) : 11065-11072
Späth, Florentin; Andersson, Ulrika; Dahlin, Anna M.; et al.
Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case-Control Study
Cancer Epidemiology, Biomarkers and Prevention, Vol. 24, (5) : 810-816
Wibom, Carl; Späth, Florentin; Dahlin, Anna M.; et al.
Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic leukemia, other lymphomas and multiple myeloma-results of the European Prospective Investigation into Cancer and Nutrition
Carcinogenesis, Vol. 35, (12) : 2716-2722
Nieters, Alexandra; Luczynska, Anna; Becker, Susen; et al.
Glioma Gwas Hits - Markers for Risk or for Prognosis?
Neuro-Oncology, Oxford University Press 2014, Vol. 16, (Suppl. 2) : ii109-ii110
Wibom, Carl; Spaeth, Florentin; Dahlin, Anna; et al.
View publications in DiVA

Research groups

Head of research
Florentin Späth lab