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Umeå University
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Dan Holmberg

Research qualifications: Docent

Contact

E-mail
dan.holmberg@umu.se
Phone

Works at

Affiliation
Affiliated as professor emeritus at Department of Medical Biosciences
Location
By 6M, vån 3, Sjukhusområdet Umeå universitet, 901 85 Umeå
Structure-function analysis of time-resolved immunological phases in metabolic dysfunction-associated fatty liver disease (MASH) comparing the NIF mouse model to human MASH
Scientific Reports, Springer Nature 2024, Vol. 14, (1)
Schmidt-Christensen, Anja; Eriksson, Gustaw; Laprade, William M.; et al.
A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis
PLOS ONE, Vol. 11, (7)
Fransen-Pettersson, Nina; Duarte, Nadia; Nilsson, Julia; et al.
Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden
BMC Medical Genetics, BioMed Central 2016, Vol. 17, (1)
Holmberg, Dan; Ruikka, Karin; Lindgren, Petter; et al.
Imaging dynamics of CD11c(+) cells and Foxp3(+) cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes
Diabetologia, Springer Berlin/Heidelberg 2013, Vol. 56, (12) : 2669-2678
Schmidt-Christensen, Anja; Hansen, Lisbeth; Ilegems, Erwin; et al.
CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes
Journal of Immunology, Vol. 188, (7) : 3138-3149
Kadri, Nadir; Korpos, Eva; Gupta, Shashank; et al.
Adoptive transfer of immunomodulatory M2 Macrophages prevents type 1 Diabetes in NOD Mice
Diabetes, American diabetes Association 2012, Vol. 61, (11) : 2881-2892
Parsa, Roham; Andresen, Pernilla; Gillett, Alan; et al.
Beta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus
PLOS ONE, Vol. 6, (12) : e29166-
Kalis, Martins; Bolmeson, Caroline; Esguerra, Jonathan LS; et al.
The Role of the Extracellular Matrix in Leukocyte Infiltration into the Pancreas of Non Obese Diabetic Mice
European Society for Microcirculation (ESM): German Society of Microcirculation and Vascular Biology (GfMVB)Munich, Germany, Berlin: Karger 2011 : 334-334
Korpos, E.; Kadri, N.; Holmberg, D.; et al.
Quantification and 3-D imaging of the insulitis-induced destruction of β-cells in murine type 1 diabetes
Diabetes, Vol. 59, (7) : 1756-1764
Alanentalo, Tomas; Hörnblad, Andreas; Mayans, Sofia; et al.
Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice.
Journal of Immunology, American Association of Immunologists 2010, Vol. 184, (5) : 2272-2280
Brauner, Hanna; Elemans, Marjet; Lemos, Sara; et al.
Fish oil delays lymphoma progression in the TLL mouse
Leukemia and Lymphoma, Vol. 51, (11) : 2092-2097
Johansson, Ann-Sofie; Norén-Nyström, Ulrika; Larefalk, Åsa; et al.
Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes.
Journal of Immunology, Vol. 184, (10) : 5537-5544
Lundholm, Marie; Mayans, Sofia; Motta, Vinicius; et al.
Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide
Leukemia and Lymphoma, Vol. 50, (7) : 1198-1203
Johansson, Ann-Sofie; Pawelzik, Sven-Christian; Larefalk, Åsa; et al.
High-resolution three-dimensional imaging of islet-infiltrate interactions based on optical projection tomography assessments of the intact adult mouse pancreas
Journal of Biomedical Optics, Bellingham, WA: SPIE--the International Society for Optical Engineering 2008, Vol. 13, (5) : 054070-
Alanentalo, Tomas; Lorén, Christina E; Larefalk, Asa; et al.
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
Cell, Vol. 135, (1) : 37-48
Cisse, Babacar; Caton, Michele L; Lehner, Manfred; et al.
Imaging the pancreas: from ex vivo to non-invasive technology.
Diabetologia, Vol. 51, (12) : 2148-2154
Holmberg, Dan; Ahlgren, Ulf
A role for E2-2 at the DN3 stage of early thymopoiesis.
Mol Immunol, Vol. 45, (11) : 3302-11
Wikström, Ingela; Forssell, Johan; Penha-Goncalves, Mario N; et al.
Tomographic molecular imaging and 3D quantification within adult mouse organs.
Nature Methods, Vol. 4, (1) : 31-33
Alanentalo, Tomas; Asayesh, Amir; Morrison, Harris; et al.
The Idd6.2 diabetes susceptibility region controls defective expression of the Lrmp gene in nonobese diabetic (NOD) mice
Immunogenetics, Vol. 59, (5) : 407-416
Duarte, Nádia; Lundholm, Marie; Holmberg, Dan
TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden
European Journal of Human Genetics, Nature Publishing Group 2007, Vol. 15, (3) : 342-346
Mayans, Sofia; Lackovic, Kurt; Lindgren, Petter; et al.
CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden
BMC Medical Genetics, Vol. 8
Mayans, Sofia; Lackovic, Kurt; Nyholm, Caroline; et al.
The NOD allele of the Idd5 locus on chromosome 1 mediates a non-cell-autonomous defect in negative selection of T cells.
Journal of Autoimmunity, Vol. 28, (4) : 216-223
Motta, Vinicius; Lejon, Kristina; Holmberg, Dan
Genome-wide linkage scan of common stroke in families from northern Sweden.
Stroke, Vol. 38, (1) : 34-40
Nilsson-Ardnor, Sofie; Janunger, Tomas; Wiklund, Per-Gunnar; et al.
Lack of aggregation of ischemic stroke subtypes within affected sibling pairs.
Neurology, Vol. 68, (6) : 427-431
Wiklund, Per-Gunnar; Brown, W M; Brott, T G; et al.
Stochastic monoallelic expression of IL-10 in T cells.
J Immunol, Vol. 177, (8) : 5358-64
Calado, Dinis Pedro; Paixáo, Tiago; Holmberg, Dan; et al.
Linkage but not association of calpain-10 to type 2 diabetes replicated in northern Sweden
Diabetes, Vol. 55, (6) : 1879-1883
Einarsdottir, Elisabet; Mayans, Sofia; Ruikka, Karin; et al.
Germ line insertions of moloney murine leukemia virus in the TLL mouse causes site-specific differences in lymphoma/leukemia frequency and tumor immunophenotype
Anticancer Research, Vol. 26, (4B) : 2873-2878
Johansson, Ann-Sofie; Eriksson, Maria; Norén-Nyström, Ulrika; et al.
A quality assessment survey of SNP genotyping laboratories
Human mutation, Vol. 27, (7) : 711-714
Lahermo, P; Liljedahl, Ulrika; Alnaes, Grethe; et al.
Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1
Diabetes, Vol. 55, (2) : 538-544
Lundholm, Marie; Motta, Vinicius; Löfgren-Burström, Anna; et al.
Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.
Neuroscience Letters, Vol. 396, (2) : 137-142
Norberg, Anna; Forsgren, Lars; Holmberg, Dan; et al.
Congenic nonobese diabetic mouse strains fail to confirm linkage of a marginal zone B lymphocyte phentoype to the Idd11 locus on chromosome 4-Response.
Journal of Immunology, Vol. 2, (176) : 702-702
Rolf, J; Motta, V; Duarte, N; et al.
Dmu expression causes enrichment of MZ B cells, but is non permissive for B cell maturation in Rag2-/- mice even if combined with Bcl-2.
Molecular Immunology, Vol. 43, (9) : 1316-1324
Wikström, Ingela; Bergqvist, Ingela; Holmberg, Dan; et al.
E2-2 regulates the expansion of pro-B cells and follicular versus marginal zone decisions.
Journal of Immunology, Vol. 177, (10) : 6723-6729
Wikström, Ingela; Forssell, Johan; Goncalves, Mario; et al.
Genetic control of parasite clearance leads to resistance to Plasmodium berghei ANKA infection and confers immunity.
Genes Immun, Vol. 6, (5) : 416-21
Campino, S; Bagot, S; Bergman, M-L; et al.
CTLA-4 (CD152) and its involvement in autoimmune disease.
Autoimmunity, Vol. 38, (3) : 225-33
Holmberg, Dan; Cilio, Corrado M; Lundholm, Marie; et al.
Homozygosity mapping of familial glioma in Northern Sweden
Acta Oncol, Vol. 44, (2) : 114-119
Malmer, Beatrice; Haraldsson, Susann; Einarsdottir, Elisabet; et al.
Linkage of ischemic stroke to the PDE4D region on 5q in a Swedish population.
Stroke, Vol. 36, (8) : 1666-1671
Nilsson-Ardnor, Sofie; Wiklund, Per-Gunnar; Lindgren, Petter; et al.
Telomere length and heredity: Indications of paternal inheritance.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, (45) : 16374-16378
Nordfjäll, Katarina; Larefalk, Asa; Lindgren, Petter; et al.
Remodeling of the innervation of pancreatic islets accompanies insulitis preceding onset of diabetes in the NOD mouse.
Journal of Neuroimmunology, Vol. 158, (1-2) : 128-37
Persson-Sjögren, Solveig; Holmberg, Dan; Forsgren, Sture
Expression of the NK-1 receptor on islet cells and invading immune cells in the non-obese diabetic mouse
Journal of Autoimmunity, Elsevier 2005, Vol. 24, (4) : 269-279
Persson-Sjögren, Solveig; Lejon, Kristina; Holmberg, Dan; et al.
The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11.
Journal of Immunology, Vol. 174, (8) : 4821-4827
Rolf, Julia; Motta, Vinicius; Duarte, Nadia; et al.
Plasminogen activator inhibitor-1 4G/5G polymorphism and risk of stroke: replicated findings in two nested case-control studies based on independent cohorts.
Stroke, Vol. 36, (8) : 1661-1665
Wiklund, Per-Gunnar; Nilsson, Lennart; Ardnor, Sofie Nilsson; et al.
Prevention of diabetes in nonobese diabetic mice mediated by CD1d-restricted nonclassical NKT cells.
Journal of Immunology, Vol. 173, (5) : 3112-3118
Duarte, Nadia; Stenström, Martin; Campino, Susana; et al.
A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.
Human Molecular Genetics, Vol. 13, (8) : 799-805
Einarsdottir, Elisabet; Carlsson, Anna; Minde, Jan; et al.
Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains
Diabetes, American Diabetes Association 2003, Vol. 52, (7) : 1677-1682
Bergman, Marie-Louise; Duarte, Nadia; Campino, Susana; et al.
The CTLA4 region as a general autoimmunity factor: an extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease
European Journal of Human Genetics, Nature Publishing Group 2003, Vol. 11, (1) : 81-84
Einarsdottir, Elisabet; Söderström, Ingegerd; Löfgren-Burström, Anna; et al.
Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1.
Neurology, Lippincott Williams & Wilkins 2002, Vol. 59, (11) : 1804-1807
Carlsson, Anna; Forsgren, Lars; Nylander, P-O; et al.
CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice
Journal of Autoimmunity, Elsevier 2001, Vol. 16, (2) : 105-113
Bergman, Marie-Louise; Cilio, Corrado M; Penha-Gonçalves, Carlos; et al.
Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region
Diabetologia, Springer 2001, Vol. 44, (8) : 1054-1061
Bergman, Marie-Louise; Penha-Gonçalves, Carlos; Lejon, Kristina; et al.
Establishment and characterization of a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia
Experimental Hematology, Vol. 27, (4) : 682-688
Eriksson, Björn; Johansson, Ann-Sofie; Roos, Göran; et al.
View publications in DiVA

Research groups

Group member
Monica Holmberg Lab