Chengjuan Qu

Senior researcher Chengjuan Qu

0000-0002-1710-7715

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Staff scientist at Department of Odontology

Byggnad 1D; våning 5, 6 och 7, byggnad 1A; våning 5 (forskarvåning), våning 7 och våning 8, byggnad 5A; våning 5, Hamrinsvägen 4; tandteknikerprogrammet, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå

Docent in Tissue Engineeering (University of Eastern Finland) Chengjuan Qu (born in Tianjin, China) graduated as a medical doctor specialized in radiology from the Tianjin Medical University in 1990, and worked as a radiologist in China 1990-1998 before moving to Kuopio, Finland.

After two maternity leaves she finished the doctoral thesis at the University of Kuopio in 2007 on articular cartilage biosynthesis and sulfation, and how glucosamine sulfate affects them.

She continued the research at the University of Kuopio focusing on cartilage tissue engineering and cell biology of mesenchymal and pluripotent stem cells.

In November 2015, she started working at the Department of Integrative Medical Biology of Umeå University. In Feburary 2019, she started working at the Department of Odontology. Units: School of Dentistry, Molecular Periodontology.

Regulation of oxygen tension as a strategy to control chondrocytic phenotype for cartilage tissue engineering and regeneration

Bioengineering, MDPI 2024, Vol. 11, (3)

Lammi, Mikko J.; Qu, Chengjuan

Fluoride releasing in polymerblends of poly(ethylene oxide) and poly(methyl methacrylate)

Frontiers in Chemistry, Frontiers Media S.A. 2024, Vol. 12

Wang, Tianxiao; Li, Menghong; Gu, Ziyan; et al.

Nano-elemental selenium particle developed via supramolecularself-assembly of chondroitin sulfate A and Na2SeO3 to repaircartilage lesions

Carbohydrate Polymers, Elsevier 2023, Vol. 316

Han, Jing; Deng, Huan; Li, Yang; et al.

Progress of selenium deficiency in the pathogenesis of arthropathies and selenium supplement for their treatment

Biological Trace Element Research, Springer Nature 2022, Vol. 200 : 4238-4249

Deng, Huan; Liu, Haobiao; Yang, Zhihao; et al.

Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease

Cartilage, Sage Publications 2022, Vol. 13, (1)

Deng, Huan; Xiao, Xiang; Chilufya, Mumba Mulutula; et al.

Engineering a 3D In Vitro Model of Human Gingival Tissue Equivalent with Genipin/Cytochalasin D

International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (13)

Koskinen Holm, Cecilia; Qu, Chengjuan

The first human induced pluripotent stem cell line of Kashin–Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway

The FEBS Journal, John Wiley & Sons 2022, Vol. 289, (1) : 279-293

Liu, Huan; Wu, Cuiyan; Zhao, Hongmou; et al.

Identification of proteins and N-glycosylation sites of knee cartilage in Kashin-Beck Disease compared with osteoarthritis

International Journal of Biological Macromolecules, Elsevier 2022, Vol. 210 : 128-138

Lyu, Yizhen; Deng, Huan; Qu, Chengjuan; et al.

Influencing factors of residents’ environmental health literacy in Shaanxi province, China: a cross‑sectional study

BMC Public Health, BioMed Central 2022, Vol. 22, (1)

Zhao, Yan; Sheng, Yun; Zhou, Jieting; et al.

Magnitude and associated factors of perceived stress and its consequence among undergraduate students of Salale University, Ethiopia: cross-sectional study

Psychology, Health & Medicine, Routledge 2021, Vol. 26, (10) : 1230-1240

Amhare, Abebe Feyissa; Jian, Lei; Wagaw, Lealem Minwuyelet; et al.

Identification of N-glycoproteins of hip cartilage in patients with osteonecrosis of femoral head using quantitative glycoproteomics

International Journal of Biological Macromolecules, Elsevier 2021, Vol. 187 : 892-902

Lu, Xueliang; Wu, Junlong; Qin, Yannan; et al.

Chondroitin Sulfate and Hyaluronic Acid Perfusion for Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis

Science Insights, Insights Publisher 2021, Vol. 39, (4) : 361-373

Xiao, Xiang; Deng, Huan; Chilufya, Mumba Mulutula; et al.

Abnormal expression of chondroitin sulfate sulfotransferases in the articular cartilage of pediatric patients with Kashin-Beck disease

Histochemistry and Cell Biology, Vol. 153, (3) : 153-164

Lei, Jian; Yan, Siqi; Zhou, Yuan; et al.

Evaluation of growth, stemness, and angiogenic properties of dental pulp stem cells cultured in cGMP xeno-/serum-free medium

Cell and Tissue Research, Springer 2020, Vol. 380 : 93-105

Qu, Chengjuan; Brohlin, Maria; Kingham, Paul J.; et al.

Serious selenium deficiency in the serum of patients with Kashin-Beck disease and the effect of nano-selenium on their chondrocytes

Biological Trace Element Research, Springer 2020, Vol. 194, (1) : 96-104

Wang, Liyun; Yin, Jiafeng; Yang, Bo; et al.

Decreased expression of CHST-12, CHST-13, and UST in the proximal interphalangeal joint cartilage of school-age children with Kashin-Beck disease: an endemic osteoarthritis in China caused by selenium deficiency

Biological Trace Element Research, New York: Springer 2019, Vol. 191, (2) : 276-285

Guo, Yijie; Zhou, Yuan; Yan, Siqi; et al.

Selenium deficiency and selenium supplements: biological effects on fibrosisin chronic diseases, from animal to human studies

Handbook of famine, starvation, and nutrient deprivation: from biology to policy, Springer 2019 : 1911-1930

Han, Jing; Guo, Xiong; Wang, Liyun; et al.

Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes

Cell and Tissue Research, New York: Springer 2019, Vol. 375, (3) : 629-639

Prittinen, Juha; Ylärinne, Janne; Piltti, Juha; et al.

Challenges in fabrication of tissue-engineered cartilage with correct cellular colonization and extracellular matrix assembly

International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (9)

Lammi, Mikko; Piltti, Juha; Prittinen, Juha; et al.

International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (9)

Lammi, Mikko; Qu, Chengjuan

Comparison of bone texture between normal individuals and patients with Kashin-Beck disease from plain radiographs in knee

Scientific Reports, Nature Publishing Group 2018, Vol. 8

Li, Wenrong; Hirvasniemi, Jukka; Guo, Xiong; et al.

Effects of long-term hypoxia in human chondrosarcoma cells

Journal of Cellular Biochemistry, John Wiley & Sons 2018, Vol. 119, (2) : 2320-2332

Piltti, Juha; Bygdell, Joakim; Qu, Chenjuan; et al.

The effects of long-term low selenium diet on the expression of CHST-3, CHST-12 and UST in knee cartilage of growing rats

Journal of Trace Elements in Medicine and Biology, Elsevier 2018, Vol. 50 : 123-129

Wang, Liyun; Guo, Xiong; Yi, Jianhua; et al.

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles

Matrix Biology, Amsterdam: Elsevier 2017, Vol. 64 : 54-68

Arasu, Uma Thanigai; Kärnä, Riikka; Härkönen, Kai; et al.

A combined experimental atomic force microscopy-based nanoindentation and computational modeling approach to unravel the key contributors to the time-dependent mechanical behavior of single cells

Biomechanics and Modeling in Mechanobiology, Springer Berlin/Heidelberg 2017, Vol. 16, (1) : 297-311

Florea, Cristina; Tanska, Petri; Mononen, Mika; et al.

Altered expression of chondroitin sulfate structure modifying sulfotransferases in the articular cartilage from adult osteoarthritis and Kashin-Beck disease

Osteoarthritis and Cartilage, Elsevier 2017, Vol. 25, (8) : 1372-1375

Han, Jing; Li, Danyang; Qu, Chengjuan; et al.

The potential of induced pluripotent stem cells as a tool to study skeletal dysplasias and cartilage-related pathologic conditions

Osteoarthritis and Cartilage, Elsevier 2017, Vol. 25, (5) : 616-624

Liu, Huan; Yang, Lei; Yu, Fang Fang; et al.

Effect of gravitational force and hydrostatic pressure on the development of articular neocartilage

Osteoarthritis and Cartilage, Elsevier 2017, Vol. 25 : S386-S386

Prittinen, Juha O.; Ylärinne, Janne H.; Piltti, Juha; et al.

Chondrocyte-specific gene expressions in human embryonic stem cells differentiated under feeder-free culture conditions

Current Regenerative Medicine, Bentham Science 2017, Vol. 7 : 54-63

Qu, Chengjuan; Lammi, Mikko

Scaffold-free approach produces neocartilage tissue of similar quality as the use of HyStem™ and Hydromatrix™ scaffolds

Journal of materials science. Materials in medicine, Springer Publishing Company 2017, Vol. 28, (4)

Ylärinne, Janne; Qu, Chengjuan; Lammi, Mikko

The effects of T-2 toxin on the prevalence and development of Kashin–Beck disease in China: a meta-analysis and systematic review

Toxicology Research, Royal Society of Chemistry 2016, Vol. 5, (3) : 731-751

Li, Danyang; Han, Jing; Guo, Xiong; et al.

Behavior of human bone marrow-derived mesenchymal stem cells on various titanium-based coatings

Materials, Basel, Switzerland: MDPI AG 2016, Vol. 9, (10)

Qu, Chengjuan; Kaitainen, Salla; Kröger, Heikki; et al.

The effects of chondroitin and/or glucosamine on patients with Kashin-Beck disease

Science Insights Medicine, Insight Publisher 2016, Vol. 2016

Wu, Xiaofang; Han, Jing; Yi, Jianhua; et al.

HyStem^TM and HydroMatrix^TM scaffolds for articular cartilage tissue engineering

Osteoarthritis and Cartilage, Elsevier 2016, Vol. 24 : S466-S466

Ylärinne, Janne; Qu, Chengjuan; Lammi, Mikko

Role of inflammation in the process of clinical Kashin-Beck disease: latest findings and interpretations

Inflammation Research, Springer 2015, Vol. 64, (11) : 853-860

Han, Jing; Wang, Weizhuo; Qu, Chengjuan; et al.

Changing grains for the prevention and treatment of Kashin-Beck disease in children: a Meta-analysis

Biomedical and environmental sciences, Chinese Center for Disease Control and Prevention 2015, Vol. 28, (4) : 308-311

Han, Jing; Yu, Fang Fang; Chang, Zai Ping; et al.

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

Amino Acids, Vienna, Austria: Springer 2015, Vol. 47, (3) : 561-570

Karjalainen, Hannu; Qu, Chengjuan; Leskelä, Stina; et al.

Nanostructured coatings for biomedical applications by ultra short pulsed laser deposition

Comprehensive guide for nanocoatings technology: Volume 3, Properties and development, Nova Science Publishers, Inc. 2015 : 309-323

Lappalainen, Reijo; Korhonen, Hannu; Kaitainen, Salla; et al.

Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells

Proteomics, Wiley-VCH Verlagsgesellschaft 2015, Vol. 15, (17) : 2953-2965

Piltti, Juha; Varjosalo, Markku; Qu, Chengjuan; et al.

Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease

Osteoarthritis and Cartilage, Elsevier 2014, Vol. 22, (11) : 1774-1783

Guo, Xiong; Ma, Wei-Juan; Zhang, Feng; et al.

Chondrocyte behavior on nanostructured micropillar polypropylene and polystyrene surfaces

Materials Science and Engineering. C, Materials for Biological Applications, Elsevier 2014, Vol. 43 : 424-431

Prittinen, Juha; Jiang, Yu; Ylärinne, Janne; et al.

Effects of freeze-thaw cycle with and without proteolysis inhibitors and cryopreservant on the biochemical and biomechanical properties of articular cartilage

Cartilage, Sage Publications 2014, Vol. 5, (2) : 97-106

Qu, Chengjuan; Hirviniemi, Mikko; Tiitu, Virpi; et al.

Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3

International Journal of Biochemistry and Cell Biology, Elsevier 2014, Vol. 48, (3) : 45-54

Qu, Chengjuan; Rilla, Kirsi; Tammi, Raija; et al.

Genome-wide study identifies the regulatory glycosyltransferase genes networks and signaling pathways from Keshan disease

Journal of Health Science, David Publishing Company 2014, Vol. 2, (4) : 165-173

Wang, Pan; Tan, Wuhong; Qu, Chengjuan; et al.

Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis.

Gene, Elsevier 2014, Vol. 535, (2) : 124-130

Wu, Shi-Xun; Wang, Wei-Zhuo; Zhang, Feng; et al.

Hypertonic conditions enhance cartilage formation in scaffold-free primary chondrocyte cultures

Cell and Tissue Research, Berlin: Springer Berlin/Heidelberg 2014, Vol. 358, (2) : 541-550

Ylärinne, Janne; Qu, Chengjuan; Lammi, Mikko

Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy.

Experimental Cell Research, Elsevier 2013, Vol. 319, (17) : 2604-2616

He, Shu-Lan; Tan, Wu-Hong; Zhang, Zeng-Tie; et al.

TiO₂ coating promotes human mesenchymal stem cell proliferation without the loss of their capacity for chondrogenic differentiation

Biofabrication, Institute of Physics (IOP) 2013, Vol. 5, (2) : 025009-

Kaitainen, Salla; Mähönen, Anssi; Lappalainen, Reijo; et al.

Osteoblast behavior on various ultra short pulsed laser deposited surface coatings

Materials Science and Engineering: C. Materials for Biological Applications, Elsevier 2013, Vol. 33, (3) : 1676-1682

Qu, Chengjuan; Myllymaa, Sami; Prittinen, Juha; et al.

Chondrogenic differentiation of human pluripotent stem cells in chondrocyte co-culture

International Journal of Biochemistry and Cell Biology, Elsevier 2013, Vol. 45, (8) : 1802-1812

Qu, Chengjuan; Puttonen, Katja; Lindeberg, Heli; et al.

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