Image: Jan Johnson
Research project What does the images mean? Correlation of in-vivo imaging with histopathology for prostate cancer.
PAMP is a multi professional effort create a greater understanding of the properties of PSMA, Acetate and mp-MRI imaging for prostate cancer through correlation with histopathology. 55 prostate cancer patients has been included in the study.
The PAMP study is a multidisciplinary initiative aimed at understanding the underlying causes of variation in how prostate tumors appear in MRI and PET images. In PAMP1, we collected data from 55 patients, including PSMA-PET, multiparametric MRI, and Acetate-PET. The images were taken before the prostate was surgically removed. By placing the excised prostate in a custom-made, patient-specific box before histopathological sectioning, we can match findings from the histopathological examination to MRI and PET images with an accuracy of below 2 mm.
Illustration of the high accuracy when registering histopathology findings to in-vivo MR and PET images
This dataset allows us to study various aspects, such as how reliably physicians can differentiate between healthy and diseased prostate tissue and whether the imaging can determine the aggressiveness of the disease. The dataset is also ideal for examining what a dose-planning strategy in radiation therapy means for dose exposure to different parts of the prostate tumor.
In the PAMP2 study we are collaborating with Lunds University to collect data for 60 more patients.
Histopathology-validated gross tumor volume delineations of intraprostatic lesions using PSMA-positron emission tomography/multiparametric magnetic resonance imaging
Physics and Imaging in Radiation Oncology, 2024
Josefine Grefve, Karin Söderkvist, Adalsteinn Gunnlaugsson, Kristina Sandgren, Joakim Jonsson, Angsana Keeratijarut Lindberg, Erik Nilsson, Jan Axelsson, Anders Bergh, Björn Zackrisson, Mathieu Moreau, Camilla Thellenberg Karlsson, Lars E. Olsson, Anders Widmark, Katrine Riklund, Lennart Blomqvist, Vibeke Berg Loegager, Sara N. Strandberg, Tufve Nyholm
Accuracy of gross tumor volume delineation with [68Ga]-PSMA-PET compared to histopathology for high-risk prostate cancer
Acta Oncologica, 2024
Maryam Zarei, Elin Wallsten, Josefine Grefve, Karin Söderkvist, Adalsteinn Gunnlaugsson, Kristina Sandgren, Joakim Jonsson, Angsana Keeratijarut Lindberg, Erik Nilsson, Anders Bergh, Björn Zackrisson, Mathieu Moreau, Camilla Thellenberg Karlsson, Lars E. Olsson, Anders Widmark, Katrine Riklund, Lennart Blomqvist, Vibeke Berg Loegager, Jan Axelsson, Sara N. Strandberg, Tufve Nyholm
The grade of individual prostate cancer lesions predicted by magnetic resonance imaging and positron emission tomography
Communications Medicine, 2023
Erik Nilsson, Kristina Sandgren, Josefine Grefve, Joakim Jonsson, Jan Axelsson, Angsana Keeratijarut Lindberg, Karin Söderkvist, Camilla Thellenberg Karlsson, Anders Widmark, Lennart Blomqvist, Sara Strandberg, Katrine Riklund, Anders Bergh, Tufve Nyholm
Histopathology-validated lesion detection rates of clinically significant prostate cancer with mpMRI, [68Ga]-PSMA-11-PET, and [11C]-Acetate-PET
Nuclear Medicine Communications, 2023
Kristina Sandgren, Sara N. Strandberg, Joakim H. Jonsson, Josefine Grefve, Angsana Keeratijarut Lindberg, Erik Nilsson, Anders Bergh, Karin Söderkvist, Camilla Thellenberg Karlsson, Bengt Friedrich, Anders Widmark, Lennart Blomqvist, Vibeke Berg Loegager, Jan Axelsson, Mattias Ögren, Margareta Ögren, Tufve Nyholm, Katrine Riklund
Registration of histopathology to magnetic resonance imaging of prostate cancer
Physics and Imaging in Radiation Oncology, 2021
Kristina Sandgren, Erik Nilsson, Angsana Keeratijarut Lindberg, Sara Strandberg, Lennart Blomqvist, Anders Bergh, Bengt Friedrich, Jan Axelsson, Margareta Ögren, Mattias Ögren, Anders Widmark, Camilla Thellenberg Karlsson, Karin Söderkvist, Katrine Riklund, Joakim Jonsson, Tufve Nyholm
