Research project In Parkinson’s disease (PD), cognitive impairments such as memory and concentration problems are common. Some of these problems can be explained by a lack of the neurotransmitter dopamine in the brain. In our previous research, we have shown that working memory training can improve certain cognitive functions and increase the amount of dopamine in the brain.
This project studies whether working memory training can improve cognitive and motor function and increase the amount of dopamine in the brain in people with Parkinson’s disease.
With the iPARK-trial, we aim to investigate the effects of working memory training in people with Parkinson’s disease. The study has a double-blinded, randomized controlled design and intends to recruit 100 people with Parkinson’s disease aged 45 to 75 years. The primary intervention is a process-based training that focuses on updating working memory, while the placebo training consists of a short-term memory program. A subgroup is offered brain imaging before and after training to illuminate changes in brain activity.
By using a comprehensive battery of neuropsychological tests, motor function, and measures of mental health, before, immediately after, and 16 weeks after completed training, the study provides an in-depth understanding of the effects of cognitive training for people with Parkinson’s disease.
The study will increase our understanding of the mechanisms behind cognitive changes as a function of working memory training and will provide important knowledge about how cognitive function can be supported in Parkinson’s disease.
