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Fatigue after traumatic brain injury

Research project Fatigue is one of the most common symptoms in patients in the chronic phase of traumatic brain injury (TBI). Despite the frequency of fatigue, and its impact on the daily life of these patients, there are no evidencebased treatments for this symptoms, nor any objective ways for diagnosis.

OSU6162 showed safe to use, causing only minor side effects. However, there were no treatment effects on fatigue after 4 weeks of treatment at a maximum dose of 15 mg twice daily. fMRI revealed effects of treatment with OSU6162, but only in regions not related to fatigue. fMRI showed that fatigue after TBI is related to alterations in striato-thalamic-cortical loops. The differences in BOLD signal in the caudate nucleus showed high diagnostic accuracy with a sensitivity of 81% and a specificity of 91%.

Project overview

Project period:

Start date: 2014-04-01

Funding

  • Vetenskapsrådet
  • Knut och Alice Wallenbergs fond

Participating departments and units at Umeå University

Department of Community Medicine and Rehabilitation

Research area

Public health and health care science

Project description

  • A clinical trial with a double-blind placebo-controlled design has been performed to examine whether the dopamine stabilizer OSU6162 has any effects on fatigue in patients with TBI. Fatigue has been examined with self-assessment scales, neuropsychological tests and functional magnetic resonance imaging (fMRI)
  • A cross-sectional study has been performed to investigate whether fMRI can be used to assess and diagnose fatigue in patients with TBI. Patients with TBI and age- and gender-matched healthy controls completed self-assessment questionnaires of fatigue, underwent an extensive neuropsychological test battery, and was examined with fMRI while performing a 27-minute fatiguing attention task.
  • Currently, another cross-sectional study is investigates whether structural damage in white matter of the brain is related to fatigue and other neuropsychological functions.
Latest update: 2018-11-13