Image: Mattias Pettersson
Image: Mattias Pettersson
Research group Our research centers on the disease amyotrophic lateral sclerosis (ALS).
Sara Rimpi, research engineer, Thomas Brännström, group leader, Erica Stenvall, PhD-student, Matthew Marklund, staff scientist, and Isabelle Sigfridsson, PhD-student, in the lab.
Image Mattias Pettersson
Matthew Marklund, staff scientist, is sectioning paraffin-embedded tissue for histopathological analysis.
Image Mattias Pettersson
Isabelle Sigfridsson, PhD-student, is adding antibodies to a glass slide with tissue sections to label them for later analysis by immunofluorscence microscopy.
Image Mattias Pettersson
Matthew Marklund, staff scientist, Isabelle Sigfridsson, PhD-student, and Sara Rimpi, research engineer, are looking at sectioned tissue samples that Isabelle has stained using immunohistochemistry.
Image Mattias Pettersson
Thomas Brännström, professor and senior pathologist, and Erica Stenvall, pathologist and a PhD-student in his research group, are looking at tissue samples stained by immunohistochemistry.
Image Mattias Pettersson
Isabelle Sigfridsson, PhD-student, is showing a colleague the results from a multiplex immunohistochemistry staining.
Image Mattias PetterssonWe study the causes behind amyotrophic lateral sclerosis (ALS), a disease that manifests through the damage and death of the nerve cells that control voluntary muscles, leading to muscle wasting and paralysis in the patient.
Our main focus is the study of a protein known as superoxide dismutase (SOD1), that when misfolded leads to protein aggregates in motor neurons. We have shown that SOD1 aggregates spread from cell to cell to give their damaging effects.
Our aim is to find ways of stopping the spread of the damaging protein and thereby impede disease progression.
Blood tests may enable more accurate diagnosis of ALS at an earlier stage of the disease, according to study.
