Research group Our research group focuses on elucidating the processes that drive the diversification of antigen recognition molecules in the immune system.
Our research is centered on the evolutionary trajectory of immune system, orchestrating the interplay between innate and adaptive immunity—an exclusive feature in vertebrates. It is marked by the generation of diverse antigen receptors through somatic recombination/assembly of the host genome. This intricate process entails the delicate balance of minimizing the risk of genome disruption, potentially leading to cancer or cell death.
Our goal is to uncover the molecular mechanisms behind this diversification and to understand how host genome editing evolved within the immune system over time.
Our research focuses on exploring non-conventional model organisms from diverse evolutionary stages, which exhibit unique immune strategies potentially shaped by host genome editing processes. Central to our work is the study of a conserved enzyme family, fundamental across the tree of life, which plays a pivotal role in genome editing and evolutionary adaptation.
We employ a multidisciplinary approach, integrating in vitro biochemistry of these enzymes, single-cell omics, advanced imaging, computational genomics, and in vivo techniques. By combining molecular, cellular, and organismal studies, we aim to uncover robust insights into the mechanisms driving immune responses and genome dynamics.
Adaptive immunity provides crucial advantages in vertebrate systems, but it also poses challenges to genome integrity, potentially leading to carcinogenesis. Moreover, the immense diversity of antigen receptors generated by this process increases the risk of autoimmunity. Understanding how host genome editing is tightly regulated is therefore critical for preserving genome stability while still benefiting from adaptive immunity.
By uncovering the finely tuned mechanisms that regulate genome editing, we aim to develop new strategies to address immune dysfunction and modulate immune-related pathophysiology. Our research holds promise for creating interventions that could prevent or mitigate immune-driven diseases. Additionally, these enzymes have the potential to serve as new experimental tools for modifying genome information.
By leveraging non-conventional animal models, our work provides evolutionary insights with broad implications for understanding human immunity and advancing innovative therapeutic and biotechnological approaches.
At our lab, we are dedicated to fostering an inclusive, multicultural, and collaborative environment. Our research delves into the molecular mechanisms that generate diversity across immune systems at various evolutionary stages, and we deeply understand the strength and beauty of diversity—not just in biology but within our team as well. We place immense value on openness, respect, and clear communication, both within and beyond our group.
Our work is grounded in the use of non-conventional model organisms, employing interdisciplinary approaches to tackle complex scientific questions. We welcome individuals with a strong internal drive, regardless of their background, and encourage self-motivation and a commitment to continuous learning and innovation.
If you're interested in joining our team, please send your CV and a letter of motivation to the PI (ryo.morimoto@umu.se). We welcome young researchers at various stages of their careers.
Our lab is committed to training early-career scientists to develop skills that meet global standards and are adaptable across fields. We provide hands-on experience in cutting-edge research while encouraging team members to pursue projects that align with their interests and ignite their curiosity.
In addition to core competencies that are relevant to their career stage, we support the development of personal skills and scientific independence, ensuring that each team member is well-equipped for their future career, regardless of the path they choose.
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MIMS welcomes Ryo Morimoto and Iker Valle Aramburu as new Group Leaders!
