NEWS Within the framework of the UCMR Distinguished Guests Seminars Series, Professor Matthew Bogyo gives a lecture on chemical probes for imaging cancer and infectious diseases. Friday 15 November - save the date!
Matthew Bogyo, Professor at Stanford University
ImageStanford UniversityTime: Friday 15 November at 15-16
Venue: Carl Kempe salen (stora hörsalen), KBC, Umeå University
Host: Ulrika Westerlind, Department of Chemistry
Registration: Registration is not needed
Matthew Bogyo, PhD. Stanford University School of Medicine, Department of Pathology
Expertise: chemical tools to image, inhibit and study hydrolases involved in cancer and infectious diseases
Hydrolases are enzymes (i.e. proteases, esterases, lipases) that often play pathogenic roles in many common human diseases such as cancer, asthma, arthritis, atherosclerosis and infection by pathogens. Therefore, tools that allow dynamic monitoring of their activity can be used as diagnostic agents, as imaging contrast agents and for the identification of novel enzymes as drug leads.
In this presentation, I will describe our efforts to design and build small molecule probes that can be used to identify, inhibit and image various hydrolase targets in models of cancer and infectious disease. This will include recent advances in protease activated fluorescent probes for real-time visualization of tumors during surgery as well our efforts to identify several new classes of serine hydrolases in pathogenic and commensal bacteria. We believe many of these enzymes will represent valuable imaging and therapy targets that can be used to visualize and disrupt various aspects of colonization and community formation inside a host.
Dr. Bogyo is a Professor of Pathology and Microbiology and Immunology at Stanford University. He received his Bachelor’s degree in Chemistry from Bates College in 1993 and a doctorate in Chemistry from Massachusetts Institute of Technology in 1997. Dr. Bogyo established an independent scientific career as a Faculty Fellow at the University of California, San Francisco. In 2001, Dr. Bogyo established the Chemical Proteomics Department at Celera Genomics focused on applying small molecule probes to the field of drug discovery. Dr. Bogyo then joined the Department of Pathology at Stanford University in July 2003 and was promoted to Associate Professor in 2009 and to full professor in 2013. Dr. Bogyo has published over 250 primary research publications and currently serves on the Editorial Board of several journals. Dr. Bogyo is also a member of Stanford’s Comprehensive Cancer Center, the Molecular Imaging Program at Stanford (MIPS) and is a consultant for several biotechnology and pharmaceutical companies in the Bay Area. He is the recipient of numerous awards including the Searle Scholar Award, The Terman Fellowship and the Burroughs Wellcome Investigators in Pathogenesis award. He is the co-founder of Akrotome Imaging, a company developing imaging contrast agents for detection of surgical margins.
Read more about Bogyo lab: https://med.stanford.edu/bogyolab.html