IceLab seminar: Single-molecule trajectories in chemically active condensates

Come to IceLab (Integrated Science Lab) Thursday the 5th of December at 10am to hear a seminar from a visiting researcher, Stefano Bo.

Stefano is visiting IceLab and Umeå University as opponent for IceLab and Department of Physics member Lucas Hedström's PhD thesis defense on December 6th. 

Single-molecule trajectories in chemically active condensates

Biomolecular condensates provide distinct chemical environments, which control various cellular processes without requiring a membrane. The diffusive dynamics and chemical kinetics of individual molecules inside condensates can be studied experimentally by fluorescent labelling, offering key insights into subcellular dynamics. I will present how biomolecular condensates govern the kinetics of chemical reactions and how this is reflected in the dynamics of labelled molecules. This will allow me to discuss how the physics of phase separation influences the evolution of single-molecule trajectories and governs their statistics. I will show that, out of equilibrium, the interactions leading to phase separation induce systematic directed motion at the level of single molecules and enhance diffusion. I will then present how we can use stochastic thermodynamics to quantify how far from equilibrium condensates are.

Drop in to IceLab (find using mazemap) or join via Zoom: IceLab Living Room Zoom 612 568 7586