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Syllabus:

Structure determination of biomolecules, 15 Credits

The course is discontinued

Swedish name: Strukturbestämning av biomolekyler

This syllabus is valid: 2012-09-17 and until further notice

Course code: 5KE140

Credit points: 15

Education level: Second cycle

Main Field of Study and progress level: Chemistry: Second cycle, has second-cycle course/s as entry requirements

Grading scale: Three-grade scale

Responsible department: Department of Chemistry

Revised by: Faculty Board of Science and Technology, 2017-10-17

Contents

The course content aims to provide a deep theoretical and experimental understanding of modern NMR and X-ray based techniques in structural biology with focus on medically and biologically relevant molecules. The main aim is that students should the understanding and be able to use of structural biology approaches to determine three-dimensional structures of soluble proteins, DNA and RNA. In addition, they should know how to   but also study insoluble biological materials such as cell membranes and their proteins (or will they solve structures of these as well?). To attain these skills students will use state of the art liquid/ solid state NMR and X-ray equipment. Applications will include the characterization of structural changes associated with biological activity, and how drugs and small organic molecules interact with biological macromolecules.

Required Knowledge

To be able to follow this course the student has to have passed: a number of chemistry courses equal to 60 ECTS and the course Advanced Experimental Tools in Chemistry (15 ECTS, 5KE125) , or the equivalent. Proficiency in English equivalent to Swedish upper secondary course English A (IELTS (Academic) with a minimum overall score of 5.5 and no individual score below 5.0. TOEFL PBT (Paper-based Test) with a minimum total score of 530 and a minimum TWE score of 4. TOEFL iBT (Internet-based Test) with a minimum total score of 72 and a minimum score of 17 on the Writing Section).
Where the language of instruction is Swedish, applicants must prove proficiency in Swedish to the level required for basic eligibility for higher studies.

Literature

The literature list is not available through the web. Please contact the faculty.