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Syllabus:

Biophysical Chemistry with Applications in Pharmaceutical Chemistry; Theory, 5.5 Credits

The course is discontinued from 2021-08-09

Swedish name: Biofysikalisk kemi med läkemedelsinriktning; Teori

This syllabus is valid: 2011-09-19 and until further notice

Course code: 5KE124

Credit points: 5.5

Education level: Second cycle

Grading scale: Pass with distinction, Pass, Fail

Responsible department: Department of Chemistry

Revised by: Faculty Board of Science and Technology, 2021-08-09

Contents

The course covers the following areas:
* Thermodynamics and chemical equilibrium, with a focus on pH, and the role of these for drug solubility in various media.
* Liquids and solutions: diffusion, viscosity, electrolyte solutions and colligative properties.
* Physical theories of mixtures and phase diagrams for two and three component systems. Gibbs phase rule.
* Polymers and physical properties of proteins. General characteristics, stability, good and less good solvents.
* Intermolecular interactions (electrostatic, induced, dispersion and hydrogen bonding) and hydrophobic effect with examples of protein-ligand interactions.
* Reaction and transport kinetics (reaction rate, reaction order, diffusion, temperature dependence) with application to dissolution and diffusion through membranes.
* Surface and Colloid Chemistry: colloid systems, wetting of surfaces, surface tension, surface activity, micelles, bilayers, colloidal forces and the DLVO theory.

Required Knowledge

For admission to the course a bachelor degree in pharmacy, including 90 ECTS pharmaceutics and pharmaceutical chemistry 30 ECTS, or 180 ECTS pharmacy degree or equivalent, are required. The eligibility requirements are also met by a bachelor's degree in chemistry with at least 90 credits in chemistry including at least 30 credits pharmaceutical chemistry or equivalent.
Proficiency in English equivalent to Swedish upper secondary course English A (IELTS (Academic) with a minimum overall score of 5.5 and no individual score below 5.0. TOEFL PBT (Paper-based Test) with a minimum total score of 530 and a minimum TWE score of 4. TOEFL iBT (Internet-based Test) with a minimum total score of 72 and a minimum score of 17 on the Writing Section). Where the language of instruction is Swedish, applicants must prove proficiency in Swedish to the level required for basic eligibility for higher studies.

Literature

The literature list is not available through the web. Please contact the faculty.