Syllabus:

Biophysical Chemistry with Applications in Pharmaceutical Chemistry, 7.5 Credits

Swedish name: Biofysikalisk kemi med läkemedelsinriktning

This syllabus is valid: 2010-12-06 and until further notice

Course code: 5KE120

Credit points: 7.5

Education level: Second cycle

Main Field of Study and progress level: Pharmacy: Second cycle, has only first-cycle course/s as entry requirements

Grading scale: Pass with distinction, Pass, Fail

Responsible department: Department of Chemistry

The course is divided into two parts: Theory (5.5 credits) and lab (2 credits). The course covers the following areas: Thermodynamics and chemical equilibrium, with a focus on pH, and the role of these for drug solubility in various media. Liquids and solutions: diffusion, viscosity, electrolyte solutions and colligative properties. Physical theories of mixtures and phase diagrams for two and three component systems. Gibbs phase rule. Polymers and physical properties of proteins. General characteristics, stability, good and less good solvents. Intermolecular interactions (electrostatic, induced, dispersion and hydrogen bonding) and hydrophobic effect with examples of protein-ligand interactions. Reaction and transport kinetics (reaction rate, reaction order, diffusion, temperature dependence) with application to dissolution and diffusion through membranes. Surface and Colloid Chemistry: colloid systems, wetting of surfaces, surface tension, surface activity, micelles, bilayers, colloidal forces and the DLVO theory.

Expected learning outcomes

After the course, the students will be able to - Understand what drives chemical reactions and connect thermodynamics to chemical equilibrium, i.e. Gibbs free energy: DeltaG° =- RTlnK - Describe fluid properties - Interpret phase diagrams and give account of Gibbs phase rule - Account for macromolecules properties - Account for different types of intermolecular interactions - Describe the basic concepts of reaction kinetics - Account for the subject of surface and colloid chemistry and be able to discuss and assess colloidal stability on the basis of DLVO theory - Perform simple calculations in the above areas - Apply the above knowledge to issues in drug development.

Required Knowledge

For admission to the course a bachelor degree in pharmacy, including 90 ECTS pharmaceutics and pharmaceutical chemistry 30 ECTS, or 180 ECTS pharmacy degree or equivalent, are required.
The eligibility requirements are also met by a bachelor's degree in chemistry with at least 90 credits in chemistry including at least 30 credits pharmaceutical chemistry or equivalent.
Proficiency in English equivalent to Swedish upper secondary course English A (IELTS (Academic) with a minimum overall score of 5.5 and no individual score below 5.0. TOEFL PBT
(Paper-based Test) with a minimum total score of 530 and a minimum TWE score of 4. TOEFL iBT (Internet-based Test) with a minimum total score of 72 and a minimum score of 17 on the Writing Section).
Where the language of instruction is Swedish, applicants must prove proficiency in Swedish to the level required for basic eligibility for higher studies.

Form of instruction

The course is online. Teaching consists of lectures (mostly in the form of video lectures), self study exercises, group seminars, demonstrations and laboratory exercises. Since the course is conducted online, most of the studies are carried out at home or in learning centers. The laboratory work is performed in Umeå. The labs are mandatory elements.

Examination modes

Examination by Mandatory laboratory work with written reports and oral seminars. A theoretical study of a drug or pharmaceutical article from a biophysical perspective. Recorded in writing and discussed in small groups through information technology, and finally presented with a poster display at the meeting in Umeå. A written examination of the theoretical understanding, with the aim to exam the students as close to home possible. The laboratory and project part of the course is only graded Fail (U) or Pass (G). The exam is graded Fail (U), Pass (G) or Pass with distinction (VG). For the whole the course the grades are Fail (U), Pass (G) or Pass with distinction (VG). To pass the course requires that all examinations and compulsory modules are approved. Students who have not been approved at the regular examination are entitled a re-examination and will be offered additional examinations by arrangement with the teacher. Students who passed a test may not resit the test to get higher scores. A student who has failed two tests is entitled to have another examiner, if not particular reasons argues against it (HF 6 Kap. 22§). Requests for new examiners are made to the Head of the Department of Chemistry. The student rights of academic credit transfer is always tested individually. For further information, see the Higher Education Ordinance.

Literature

Valid from: 2010 week 45

Chang Raymond.
Physical chemistry for the biosciences
Sansalito, CA : University Science : 2005 : xiii, 677 p. :
ISBN: 1-891389-33-5 (alk. paper)
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